ALISKIREN AND VALSARTAN LIMIT MYOCARDIAL INFARCT SIZE IN DIABETIC MICE
نویسندگان
چکیده
منابع مشابه
Haptoglobin genotype determines myocardial infarct size in diabetic mice.
OBJECTIVES We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). BACKGROUND Two common alleles (1 and 2) exist at the Hp locus in humans. The Hp 2 allele is associated with increased MI size in individuals with DM. In vitro, the Hp 2 protein is associated with increased g...
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The mortality rate from myocardial infarction is disproportionately high in diabetic patients. One explanation for this may be that diabetic patients incur more extensive myocardial necrosis. This possibility was examined in a three part study. Firstly, peak serum aspartate aminotransferase concentrations of all diabetic and non-diabetic patients admitted with myocardial infarction over a 16 ye...
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Recent infarcts were compared with the anatomic boundaries of the involved vascular bed in human hearts to determine the amount and location of necrosis in relation to the myocardium at risk. The coronary arteries were injected with BaSo4 in 18 human hearts with 3-16-day-old infarcts. Thin (3-4-mm) slices were cut at 10-15-mm intervals, photographed, x-rayed and used for histologic analysis. In...
متن کاملMyocardial Infarct Size in Humans
Background. The influence of coronary collateral vessels on infarct size in humans remains controversial, partly because no previous study has examined the impact of collaterals present at the onset of acute myocardial infarction on infarct size. Methods and Results. The present study used the data base of the Thrombolysis in Myocardial Infarction (TIMI) Phase I trial to correlate the presence ...
متن کاملRelationship Between Myocardial Infarct Size
We compared myocardial infarct size produced by permanent occlusion of the middle left anterior descending (LAD) or circumflex (LCx) coronary artery in the anesthetized dog. The dogs were killed 3-10 days later, and the occluded coronary bed was visualized by postmortem arteriography. The outlines of the infarct and occluded bed were marked on tracings of weighed left ventricular (LV) rings and...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2011
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(11)61012-7